To find the percentage difference between two numbers, we first need to calculate the absolute difference between them. In this case, the absolute difference between 75 and 250 is 175 (250 - 75 = 175).

Next, we need to find what percentage this difference represents in relation to the original number. To do this, we divide the absolute difference by the average of the two numbers and then multiply by 100. The average of 75 and 250 is (75 + 250) / 2 = 162.5.

So, the percentage difference between 75 and 250 is:

| (250 - 75) / ((75 + 250) / 2) | x 100
= | 175 / 162.5 | x 100
= 107.69%

Therefore, the percentage difference between 75 and 250 is 107.69%. This means that 250 is 107.69% more than 75.