The percentage difference between 50 and 5 is calculated by finding the absolute difference between the two numbers, which is 45, and then dividing it by the average of the two numbers, which is 27.5.

So, the percentage difference can be calculated as follows:

Percentage Difference = (Absolute Difference / Average) x 100

= (45 / 27.5) x 100

= 163.64%

Therefore, the percentage difference between 50 and 5 is 163.64%. This means that 50 is 163.64% greater than 5.