To find the percentage difference between two numbers, we first need to calculate the absolute difference between them. In this case, the absolute difference between 481 and 52 is 429.

Next, we need to find the average of the two numbers. The average of 481 and 52 is (481+52)/2 = 266.5.

Now, we can calculate the percentage difference by dividing the absolute difference by the average and multiplying by 100. So, the percentage difference between 481 and 52 is (429/266.5) x 100 = 161.1%.

This means that the second number (52) is 161.1% less than the first number (481). Alternatively, we can say that the first number is 161.1% greater than the second number.