To find the percentage difference between two numbers, we first need to calculate the absolute difference between them. In this case, the absolute difference between 368 and 16 is 352 (i.e., |368 - 16| = 352).

Next, we need to find the average of the two numbers. The average of 368 and 16 is (368 + 16) / 2 = 192.

Now, we can calculate the percentage difference by dividing the absolute difference by the average and multiplying by 100. So, the percentage difference between 368 and 16 is (352 / 192) x 100 = 183.33%.

Therefore, the percentage difference between 368 and 16 is 183.33%. This means that the two numbers are quite different from each other, with one being almost twice as large as the other.