To find the percentage difference between two numbers, we first need to find the absolute difference between them. In this case, the absolute difference between 336 and 48 is 288 (336 - 48 = 288).

Next, we need to find the average of the two numbers. The average of 336 and 48 is (336 + 48) / 2 = 192.

Now, we can calculate the percentage difference by dividing the absolute difference by the average and multiplying by 100. So, the percentage difference between 336 and 48 is (288 / 192) x 100 = 150%.

This means that the second number (48) is 150% less than the first number (336). Alternatively, we can say that the first number (336) is 200% more than the second number (48).