To find the percentage difference between two numbers, we first need to calculate the absolute difference between them. In this case, the absolute difference between 330 and 250 is 80.

Next, we need to find the average of the two numbers. The average of 330 and 250 is (330+250)/2 = 290.

Now, we can calculate the percentage difference by dividing the absolute difference by the average and multiplying by 100. So, the percentage difference between 330 and 250 is (80/290) x 100 = 27.59%.

Therefore, the percentage difference between 330 and 250 is 27.59%. This means that the two numbers differ by 27.59% of their average value.