To find the percentage difference between two numbers, we first need to find the absolute difference between them. In this case, the absolute difference between 250 and 149 is 101.

Next, we need to find what percentage this absolute difference is of the original number. To do this, we divide the absolute difference by the average of the two numbers (which is (250+149)/2 = 199.5) and then multiply by 100 to get the percentage.

So, the percentage difference between 250 and 149 is:

(101 / 199.5) x 100 = 50.63%

Therefore, the percentage difference between 250 and 149 is 50.63%. This means that the difference between the two numbers is more than half of the average of the two numbers.